Cloud instance comparison · Prices checked July 2026
AWS m5.4xlarge vs Azure Standard_D16s_v5
AWS m5.4xlarge and Azure Standard_D16s_v5 are priced identically at $560.64/month on-demand, for matching specs of 16 vCPU and 64 GiB of memory. This comparison uses AWS's us-east-1 and Azure's eastus baseline on-demand Linux pricing — with no list-price gap, the decision comes down to ecosystem fit rather than cost.
Specs & pricing side by side
| Spec | AWS m5.4xlarge | Azure Standard_D16s_v5 |
|---|---|---|
| vCPU | 16 | 16 |
| Memory | 64 GiB | 64 GiB |
| Region (baseline) | us-east-1 | eastus |
| Hourly (on-demand) | $0.7680 | $0.7680 |
| Monthly (730 hrs) | $560.64 | $560.64 |
| Price difference | Priced identically — no on-demand list-price difference | |
Which one should you pick?
Since AWS m5.4xlarge and Azure Standard_D16s_v5 are priced identically at this spec tier, price should not be the deciding factor. Pick AWS m5.4xlarge if you're already building on AWS — existing networking, IAM, and tooling outweigh a tie on list price.
Pick Azure Standard_D16s_v5 if Azure is your existing ecosystem instead, or if you value a specific managed service, region footprint, or support plan that AWS doesn't offer.
Either way, this is a single-instance, on-demand comparison. Reserved/committed-use discounts (up to ~72% on both platforms) and your actual utilization pattern will move the real numbers — model your full workload with the calculator before deciding.
Frequently asked questions
Is AWS m5.4xlarge cheaper than Azure Standard_D16s_v5?
No — they're priced identically. Both cost $560.64/mo on-demand for 16 vCPU and 64 GiB of memory. The choice comes down to ecosystem fit, not price.
What are the specs of AWS m5.4xlarge?
AWS m5.4xlarge provides 16 vCPU and 64 GiB of memory, priced at $0.7680/hour on-demand ($560.64/month at 730 hours) in the us-east-1 baseline region.
How much does AWS m5.4xlarge cost per month compared to Azure Standard_D16s_v5?
At 730 hours/month, both AWS m5.4xlarge and Azure Standard_D16s_v5 cost $560.64. There is no on-demand list-price difference between them at this spec tier.
Prices checked July 2026. Baseline regions: AWS pricing uses us-east-1, Azure uses eastus. All prices are on-demand Linux, list rate, before reserved/committed-use discounts. See our methodology for pricing sources, update cadence, and mapping rules.
Model your full stack, not just one instance
A single instance is one line item. Use the free SpendArk calculator to compare AWS, Azure, GCP, and DigitalOcean across your whole architecture — compute, database, storage, and networking together.
Open the cloud cost calculator →Related comparisons
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For a deeper dive on AWS vs Azure pricing beyond a single instance, read our full pricing comparison guide.